主要从事中枢神经系统肿瘤与炎症的转化研究,注重阐述疾病发展规律和开发靶向微环境治疗的新策略。利用全基因组测序、单细胞转录组测序、空间组学以及代谢组学分析,深入研究肿瘤微环境对中枢神经系统的影响;结合中枢神经系统肿瘤小鼠模型探究新靶点的生物学功能、有效性和安全性;建立基于仿生纳米材料的中枢神经系统药物递送系统,对肿瘤细胞与微环境进行干预治疗。
1 中枢神经系统肿瘤微环境时空演进规律
2 肿瘤微环境代谢重编程
3 中枢神经系统药物递送与靶向治疗
4 中枢神经系统肿瘤或炎症引起颅内的损伤机制
5 脑脊液中肿瘤标志物的鉴定与生物学功能的分析
邮箱:hbpeng@fudan.edu.cn
研究方向:中枢神经系统药物递送、仿生纳米医学、刺激响应性功能材料
邮箱:shenxia@@fudan.edu.cn
研究方向:代谢组学与多组学整合,肿瘤代谢与免疫
邮箱:jiaxuzhao@fudan.edu.cn
研究方向:脑膜转移与免疫微环境
邮箱:huang_yang@fudan.edu.cn
研究方向:脑转移瘤外泌体的作用和调控机制
邮箱:646825836@qq.com
研究方向:无
邮箱:joyezhang313@163.com
研究方向:中枢神经系统肿瘤代谢调控
邮箱:22111520003@m.fudan.edu.cn
研究方向:肿瘤脑转移干细胞功能学研究
邮箱:21211520016@m.fudan.edu.cn
研究方向:软脑膜转移瘤细胞运动与免疫学研究
邮箱:23111520067@m.fudan.edu.cn
研究方向:软脑膜转移瘤肿瘤微环境
邮箱:23211520048@m.fudan.edu.cn
研究方向:中枢神经系统药物递送
邮箱:rzeng18@fudan.edu.cn
研究方向:硬脑膜巨噬细胞在软脑膜转移瘤中的作用机制研究
邮箱:21301050205@m.fudan.edu.cn
研究方向:软脑膜转移瘤的外泌体功能
邮箱:22301050004@m.fudan.edu.cn
研究方向:软脑膜转移瘤细胞运动与免疫学研究
邮箱:22301030076@m.fudan.edu.cn
研究方向:致痫性胶质瘤发病机制
邮箱:22301030056@m.fudan.edu.cn
研究方向:中枢神经系统药物递送
邮箱:1010973867@qq.com
研究方向:暂无
邮箱:20301050279@fudan.edu.cn
研究方向:肿瘤软脑膜转移
Pan L#, Peng H#, Lee B, Zhao J, Shen X, Yan X, Hua Y, Kim J, Kim D, Lin M, Zhang S, Li X, Yi X, Yao F, Qin Z, Du J, Chi Y*, Nam J*, Hyeon T*, Liu J *(2023). Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis. Advanced Materials, Online
Peng H, Yao F, Zhao J, Zhang W, Chen L, Wang X, Yang P*, Tang J*, Chi Y* (2023). Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials. Exploration, 3(2):20220115
Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe'er D, Mazutis L, Boire A*(2020). Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science, 369(6501):276-282.
Remsik J, Chi Y, Tong X, Sener U, Derderian C, Park A, Saadeh F, Bale T, Boire A*(2020) Leptomeningeal metastatic cells adopt two phenotypic states. Cancer Reports, e1236.
Zhang T, Choi S, Zhang T, Chen Z, Chi Y, Huang S, Xiang JZ, Du YN*(2020). miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor. Am J Pathol, 190(3):689-701
Wang X, Fang Z, Xiong J, Yang K, Chi Y, Tang X, Ma L, Zhang R, Deng F, Lan K, Zhou D*(2019). A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge. Virology, 536:32-38.
Zhang G, Chi Y, Du YN*(2017). Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model. J Vis Exp, (128):55890.
Zhang C, Chi Y, Zhou D*(2017). Development of Novel Vaccines Against Infectious Diseases Based on Chimpanzee Adenoviral Vector. Methods Mol Biol, 1581:3-13.
Wang X, Fu W, Yuan S, Yang X, Song Y, Liu L, Chi Y, Cheng T, Xing M, Zhang Y, Zhang C, Yang Y, Zhu C, Zhang X, Xiong S, Xu J, Zhou D*(2017). Both haemagglutinin-specific antibody and T cell responses induced by a chimpanzee adenoviral vaccine confer protection against influenza H7N9 viral challenge. Sci Rep, 7(1):1854.
Cheng T, Song Y, Zhang Y, Zhang C, Yin J, Chi Y, Zhou D*(2017). A novel oncolytic adenovirus based on simian adenovirus serotype 24. Oncotarget, 8(16):26871-26885.
Chi Y, Zhou D*(2016). MicroRNAs in colorectal carcinoma--from pathogenesis to therapy. J Exp Clin Cancer Res, 10;35:43.
Xing M, Wang X, Chi Y, Zhou D* (2016). Gene therapy for colorectal cancer using adenovirus-mediated full-length antibody, cetuximab. Oncotarget, 7(19):28262-72.
Yang Y, Chi Y, Tang X, Ertl HCJ, Zhou D*(2016). Rapid, Efficient, and Modular Generation of Adenoviral Vectors via Isothermal Assembly. Curr Protoc Mol Biol, 113(1):16.26.1-16.26.18.
Zhang C, Yang Y, Chi Y, Yin J, Yan L, Ku Z, Liu Q, Huang Z, Zhou D*(2015). Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71. Vaccine, 33(39):5087-94
Chi Y, Wang X, Yang Y, Zhang C, Ertl HC, Zhou D*(2014). Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models. Mol Ther Nucleic Acids, 3(11):e208.
地址: 海市徐汇区东安路131号科研2号楼二楼
邮编: 200032
电话/传真: 021-54237012
邮箱: chiy@fudan.edu.cn