本实验室应用单细胞测序、高通量筛选和多组学分析等技术,系统研究肿瘤细胞的表观遗传调控及与微环境的相互作用,深入挖掘脑疾病大数据,发现新的治疗靶点和标志物。
实验室主要研究方向包括:
1.脑肿瘤表观遗传和转录机制
2.肿瘤免疫靶点的系统生物学分析
3.脑疾病的多组学分析和深度学习
实验室欢迎对肿瘤、神经退行性疾病和生物信息分析感兴趣的博士后、研究生和实习生加入!
Zhixin Qiu#, Linjie Zhao#, Jia Z Shen#, Zhengyu Liang, Qiulian Wu, Kailin Yang, Lihua Min, Ryan Gimple, Qiyuan Yang, Shruti Bhargava, Chunyu Jin, Cheryl Kim, Denise Hinz, Deobrat Dixit, Jean Bernatchez, Briana Prager, Guoxin Zhang, Zhen Dong, Deguan Lv, Xujun Wang, Leo Kim, Zhe Zhu, Katherine jones, Ye Zheng, Xiuxing Wang, Jair Siqueira-Neto, Lukas Chavez, Xiangdong Fu, Charles Spruck, and Jeremy Rich. Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells. Cancer Discovery 2021 online.
Jia Z Shen#, Zhixin Qiu#, Qiulian Wu, Darren Finlay, Guillermina Garcia, Dahui Sun, Juha Rantala, William Barshop, Jennifer L Hope, Ryan C Gimple, Olle Sangfelt, Linda M Bradley, James Wohlschlegel, Jeremy N Rich*, Charles Spruck*. FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells. Cell 2021; 184(2):352-369.e23.
Zhixin Qiu#, Hong Li#, Zhengtao Zhang#, Zhenfeng Zhu, Sheng He, Xujun Wang, Pengcheng Wang, Jianjie Qin, Liping Zhuang, Wei Wang, Fubo Xie, Ying Gu, Keke Zou, Chao Li, Chun Li, Chenhua Wang, Jin Cen, Xiaotao Chen, Yajing Shu, Zhao Zhang, Lulu Sun, Lihua Min, Yong Fu, Xiaowu Huang, Hui Lv, He Zhou, Yuan Ji, Zhigang Zhang, Zhiqiang Meng, Xiaolei Shi*, Haibin Zhang*, Yixue Li*, Lijian Hui*. A Pharmacogenomic Landscape in Human Liver Cancers. Cancer Cell 2019; 36(2):179-193.e11.
Zhixin Qiu#, Keke Zou#, Liping Zhuang#, Jianjie Qin#, Hong Li, Chao Li, Zhengtao Zhang, Xiaotao Chen, Jin Cen, Zhiqiang Meng*, Haibin Zhang*, Yixue Li*, Lijian Hui*. Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers. Scientific Reports 2016; 27411.
地址: 上海市徐汇区东安路131号二号医学科研楼B座二楼
邮编: 200032
电话/传真: 021-54237056
邮箱: qiuzhixin@fudan.edu.cn