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Neural circuit analysis of brain function

Engaged in neuroscience research for many years, Shumin Duan has made systematic innovations in neuron-glial cell interaction, synaptic development and function, and neural circuit analysis for precise regulation of brain function.

Research directions include:

1. The regulation mechanism of ATP released by glial cells on synaptic plasticity;

2. The transport and release mechanism of neuronal presynaptic vesicles;

3. The transport and release mechanism of microglia vesicles;

4. Early neuronal network formation;

5. The neural circuit basis of mood and mood-related diseases.

The research methods mainly include:

1. Single and double patch clamp recordings in cultured neurons and isolated brain slices;

2. Morphological studies of confocal and electron imaging;

3. Live-cell time-lapse imaging, combined with protein transfection with GFP for the study of the dynamic distribution of some important protein molecules, organelle movement and vesicle secretion;

4. Using transgenic animals and conditional gene knockout mice produced by the use of glial cell specific molecules as promoters and the Cre-LoxP system to interfere with the specific molecules in the glia for investigating the roles of glial cells in various neurological functions;

5. Combined optogenetics, animal behavior with virus reverse tracking to study the roles of specific types of neurons in emotion or disease-related neural circuits.

Engaged in neuroscience research for many years, Shumin Duan has made systematic innovations in neuron-glial cell interaction, synaptic development and function, and neural circuit analysis for precise regulation of brain function.

Research directions include:

1. The regulation mechanism of ATP released by glial cells on synaptic plasticity;

2. The transport and release mechanism of neuronal presynaptic vesicles;

3. The transport and release mechanism of microglia vesicles;

4. Early neuronal network formation;

5. The neural circuit basis of mood and mood-related diseases.

The research methods mainly include:

1. Single and double patch clamp recordings in cultured neurons and isolated brain slices;

2. Morphological studies of confocal and electron imaging;

3. Live-cell time-lapse imaging, combined with protein transfection with GFP for the study of the dynamic distribution of some important protein molecules, organelle movement and vesicle secretion;

4. Using transgenic animals and conditional gene knockout mice produced by the use of glial cell specific molecules as promoters and the Cre-LoxP system to interfere with the specific molecules in the glia for investigating the roles of glial cells in various neurological functions;

5. Combined optogenetics, animal behavior with virus reverse tracking to study the roles of specific types of neurons in emotion or disease-related neural circuits.

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