Engaged in neuroscience research for many years, Shumin Duan has made systematic innovations in neuron-glial cell interaction, synaptic development and function, and neural circuit analysis for precise regulation of brain function.
Research directions include:
1. The regulation mechanism of ATP released by glial cells on synaptic plasticity;
2. The transport and release mechanism of neuronal presynaptic vesicles;
3. The transport and release mechanism of microglia vesicles;
4. Early neuronal network formation;
5. The neural circuit basis of mood and mood-related diseases.
The research methods mainly include:
1. Single and double patch clamp recordings in cultured neurons and isolated brain slices;
2. Morphological studies of confocal and electron imaging;
3. Live-cell time-lapse imaging, combined with protein transfection with GFP for the study of the dynamic distribution of some important protein molecules, organelle movement and vesicle secretion;
4. Using transgenic animals and conditional gene knockout mice produced by the use of glial cell specific molecules as promoters and the Cre-LoxP system to interfere with the specific molecules in the glia for investigating the roles of glial cells in various neurological functions;
5. Combined optogenetics, animal behavior with virus reverse tracking to study the roles of specific types of neurons in emotion or disease-related neural circuits.
Address:No.138, medical college road 
Postcode:200032 
Tel/Fax:021-54237056
Emial:itbr@fudan.edu.cn220 Handan Rd., Shanghai(200433) Operator：+86-21-65642222 © 2019 FUDAN UNIVERSITY.
