突触形成和突触传递是大脑信息处理和脑功能实现的基础。研究突触形成和突触传递有助于理解脑功能的神经机制，并解析神经退行性疾病的病理机制。课题组结合分子生物学、原代神经元培养、电生理、超分辨显微成像、电镜成像、光纤记录和行为学分析等技术，探究突触形成和突触传递的分子机制，解析其在神经退行性疾病进程中的病理改变，为相关疾病的改善和治疗开发新的分子工具。
Chao Tan, Shan Shan H. Wang, Giovanni de Nola, Pascal S. Kaeser. Rebuilding essential active zone functions within a synapse, Neuron, 2022, 110(9): 1498-1515.
Chao Tan, Giovanni de Nola, Claire Qiao, Cordelia Imig, Richard T. Born, Nils Brose, Pascal S. Kaeser. Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones, eLife, 2022, 11: e79077.
Chao Tan*, Nan-Nan Lu*, Cheng-Kun Wang, Dan-Yang Chen, Ning-He Sun, Hang Lyu, Jakob Körbelin, Wei-Xing Shi, Kohji Fukunaga, Ying-Mei Lu, Feng Han. Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4, Neuron, 2019, 101(5): 920-937.
Nan-Nan Lu*, Chao Tan*, Ning-He Sun, Ling-Xiao Shao, Xiu-Xiu Liu, Yin-Ping Gao, Rong-Rong Tao, Quan Jiang, Cheng-Kun Wang, Ji-Yun Huang, Kui Zhao, Guang-Fa Wang, Zhi-Rong Liu, Kohji Fukunaga, Ying-Mei Lu, Feng Han. Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function, Cerebral Cortex, 2018, 28(7): 2391-2404.
Shishi Li*, Huaye Pan*, Chao Tan*, Yaping Sun, Yanrui Song, Xuan Zhang, Wei Yang, Xuexiang Wang, Dan Li; Yu Dai, Qiang Ma, Chenming Xu, Xufen Zhu, Lijun Kang, Yong Fu, Xuejun Xu, Jing Shu, Naiming Zhou, Feng Han, Dajiang Qin, Wendong Huang, Zhong Liu, Qingfeng Yan. Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation, Stem Cell Reports, 2018, 10(3): 808-821.
Xing-Guang Liang, Chao Tan, Cheng-Kun Wang, Rong-Rong Tao, Yu-Jie Huang, Kui-Fen Ma, Kohji Fukunaga, Ming-Zhu Huang, Feng Han. Myt1l induced direct reprogramming of pericytes into cholinergic neurons, CNS Neuroscience & Therapeutics, 2018, 24(9): 801-809.
地址: 上海市徐汇区东安路131号医学科研楼二楼
邮编: 200032
电话/传真: 021-54237056
邮箱: chao_tan@fudan.edu.cn
地址：上海市徐汇区医学院路138号，邮编：200032，电话：54237056，版权所有·bwin·必赢(中国)唯一官方网站
地址：上海市徐汇区医学院路138号 
邮编：200032 
电话/传真：021-54237056 