利用生物化学、分子细胞生物学、行为学等方法，在来自于患者的诱导干细胞、类脑器官以及小鼠等多个层次的疾病模型中，对神经退行性疾病的分子细胞机理进行深入研究，重点关注代谢调控在疾病中的作用，旨在发现重要的致病分子通路并探索可行的治疗靶点，推动基础研究成果的临床转化。
Wang, T. #*, Tian, X#., Kim, H. B., Jang, Y., Huang, Z., Na, C. H. and Wang, J*. Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules. Nature communications 2022, 13, 5584. (Co-first and co-corresponding author)
Wang T, Liu H, Itoh K, Oh S, Zhao L, Murata D, Sesaki H, Hartung T, Na C, Wang J. C9orf72 Regulates Energy Homeostasis by Stabilizing Mitochondrial Complex I Assembly. Cell Metabolism 2021, 33(3): 531-546 e539.
Xu W, Bao P, Jiang X, Wang H, Qin M, Wang R, Wang T, Yang Y, Lorenzini I, Liao L, Sattler R, Xu J. Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity. Brain 2019, 142(5): 1349-1364.
Liu Y, Wang T, Ji YJ, Johnson K, Liu H, Bailey S, Suk Y, Lu YN, Liu M, Wang J. A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress. Genes & development 2018, 32(21-22): 1380-1397.
Jiang X, Zhang T, Wang H, Wang T, Qin M, Bao P, Wang R, Liu Y, Chang HC, Yan J, Xu J. Neurodegeneration-associated FUS is a novel regulator of circadian gene expression. Translational neurodegeneration 2018, 7: 24
Wang T, Xu W, Qin M, Yang Y, Bao P, Shen F, Zhang Z, Xu J. Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response. The Journal of biological chemistry 2016, 291(27): 14373-14384.
Wang T#, Jiang X#, Chen G, Xu J. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Neurobiology of aging 2015, 36(1): 527-535.
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邮编: 200032
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邮箱: wang_tao@fudan.edu.cn
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地址：上海市徐汇区医学院路138号 
邮编：200032 
电话/传真：021-54237056 