课题组主要利用电生理、离子成像、形态学、光/化学遗传学和病毒示踪等技术方法,研究神经元和神经网络电活动的形成机理和编码机制;探讨脑内各类型神经元的局部环路和跨脑区环路的突触连接特点及其在脑功能实现中的重要生理作用、在脑疾病发生发展过程中的病理作用;鉴定可调控神经元兴奋性和环路功能的重要分子;发展化学或物理的神经调控新技术。近期的研究项目有:
(1)离子通道对神经元兴奋性及其环路功能的调控。
(2)突触传递对神经元电活动和环路功能的调节作用。
(3)功能神经环路(介导本能行为和运动控制等)的神经元种类与突触连接特点。
(4)脑疾病机制及其神经调控新策略(癫痫、帕金森病等病理机制及脑刺激治疗新方法)。
邮箱:tangm@fudan.edu.cn
研究方向:微纳神经电极研发与神经调控
邮箱:xiaoxue@fudan.edu.cn
研究方向:实验室技术与管理
邮箱:sun21064@163.com
研究方向:电生理、形态学、行为学技术
邮箱:sxdeng@fudan.edu.cn
研究方向:深部脑刺激的环路机制及应用
邮箱:weike@fudan.edu.cn
研究方向:离子通道与神经元兴奋性
邮箱:He_quansheng@fudan.edu.cn
研究方向:癫痫网络活动的产生和传播机制
邮箱:liuxifd@fudan.edu.cn
研究方向:神经调控新技术研发及应用
邮箱:lijunlong@fudan.edu.cn
研究方向:神经元兴奋性与情绪调节
邮箱:lshuxuan@fudan.edu.cn
研究方向:帕金森病相关抑郁的产生与调节机制
邮箱:11918104@zju.edu.cn
研究方向:多巴胺神经元的选择性丢失机制
邮箱:lil21@m.fudan.edu.cn
研究方向:神经元兴奋性与离子通道疾病
邮箱:20111520036@fudan.edu.cn
研究方向:深部脑刺激的环路机制及应用
邮箱:21111520026@m.fudan.edu.cn
研究方向:自闭症的突触与环路机制
邮箱:wduan20@fudan.edu.cn
研究方向:癫痫的分子与细胞机制
邮箱:20111520041@fudan.edu.cn
研究方向:神经元发放模式及功能
邮箱:zhangxiaowen20@fudan.edu.cn
研究方向:基底节神经元的突触传递特性
邮箱:qhuang21@m.fudan.edu.cn
研究方向:自闭症样行为的细胞和环路机制
邮箱:20111210064@fudan.edu.cn
研究方向:局灶性皮质发育不良导致癫痫的病理机制
邮箱:19301030047@fudan.edu.cn
研究方向:神经退行性疾病及干预策略
Deng S, Li J, He Q, Zhang X, Zhu J, Li L, Mi Z, Yang X, Jiang M, Dong Q, Mao Y, Shu Y*. (2020) Regulation of recurrent inhibition by asynchronous glutamate release in neocortex. Neuron. pii: S0896-6273(19)30933-X. doi: 10.1016/j.neuron.2019.10.038. ***
Yang J, Xiao Y, Li L, He Q, Li M and Shu Y*. (2019) Biophysical properties of somatic and axonal voltage-gated sodium channels in midbrain dopaminergic neurons. Frontiers in Cellular Neuroscience. 13:317. doi: 10.3389/fncel.2019.00317.
Yin L#, Zheng R#, Ke W#, He Q#, Zhang Y, Li J, Wang B, Mi Z, Long YS, Rasch MJ, Li T, Luan G, Shu Y*. (2018) Autapses enhance bursting and coincidence detection in neocortical pyramidal cells. Nature Communications. 9(1):4890. doi: 10.1038/s41467-018-0
Yin L, Rasch M, He Q, Wu S, Dou F and Shu Y*. (2017) Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cerebral Cortex. 27(1):509-521. ***
Wang B, Yin L, Zou X, Ye M, Liu Y, He T, Deng S, Jiang Y, Zheng R, Wang Y, Yang M, Lu H, Wu S and Shu Y*. (2015) A Subtype of Inhibitory Interneuron with Intrinsic Persistent Activity in Human and Monkey Neocortex. Cell Reports, Doi.org/10.1016/j.celre
Jiang M, Yang M, Yin L, Zhang X, and Shu Y*. (2015) Developmental reduction of asynchronous GABA release from neocortical fast-spiking neurons, Cerebral Cortex. 25(1):258-70. ***
Tian C, Wang K, Ke W, Guo H, Shu Y*. (2014) Molecular identity of axonal sodium channels in human cortical pyramidal cells. Frontiers in Cellular Neuroscience. DOI:10.3389/fncel.2014.00297
Li T, Tian C, Scalmani P, Frassoni C, Mantegazza M, Wang Y, Yang M, Wu S, Shu Y*. (2014) Action potential initiation in neocortical inhibitory interneurons. PLoS Biology. 12(9):e1001944. ***
Yang J, Ye M, Tian C, Yang M, Wang Y, and Shu Y*. (2013) Dopaminergic Modulation of Axonal Potassium Channel and Action Potential Waveform in Pyramidal Neurons of Prefrontal Cortex. Journal of Physiology. 591: 3233-3251. ***
Jiang M, Zhu J, Liu Y, Yang M, Tian C, Jiang S, Wang Y, Guo H, Wang K and Shu Y*. (2012) Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex. PLoS Biology. 10: e1001324. ***
Zhu J, Jiang M, Yang M, Hou H and Shu Y*. (2011) Membrane potential-dependent modulation of recurrent inhibition in rat neocortex. PLoS Biology. 9(3): e1001032. (synopsis: Finding Balance in Cortical Networks.) ***
Hu W, Tian C, Li T, Yang M, Hou H, Shu Y*. (2009) Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation. Nature Neuroscience. 12: 996-1002. (News and Views: Who let the spikes out?). ***
Shu Y, Yu YG, Yang J and McCormick DA*. (2007b) Selective control of cortical axonal spikes by a slowly inactivating K+ current. PNAS. 104(27):11453-8. ***
Shu Y, Duque A, Yu Y, Haider B and McCormick DA*. (2007a) Properties of action potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of Neurophysiology. 97(1):746-760.
McCormick DA*, Shu Y and Yu Y. (2007) Neurophysiology: Hodgkin and Huxley model--still standing? Nature. 445(7123):E1-E2.
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA* (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature. 441: 761-765. Coments by Eve Marder: Extending influence. Nature. 441: 702-703. ***
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick DA* (2005) Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks. Neuron. 47(3): 423-435. ***
Shu Y, Hasenstaub A, McCormick DA* (2003) Turning on and off recurrent balanced cortical activity. Nature. 423: 288-293. ***
Shu Y, Hasenstaub A, Badoual M, Bal T and McCormick DA* (2003) Barrages of synaptic activity control the gain and sensitivity of cortical neurons. Journal of Neuroscience. 23: 10388-10401
Shu Y and McCormick DA* (2002) Inhibitory interactions between ferret thalamic reticular neurons. Journal of Neurophysiology. 87(5): 2571-2576.
地址: 上海市东安路131号医学科研2号楼B座二楼
邮编: 200032
电话/传真: 021-54237723
邮箱: yousheng@fudan.edu.cn