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Feifan Guo

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Feifan Guo Professor

Nutrition and Obesity-related Metabolic Diseases

Dr. Guo is a professor and vice president at the Institute for Translational Brain Research (ITBR), Fudan University. Dr. Guo obtained her Ph.D. in Neuroscience from the University of Tokyo in 2001. After that, she did postdoc training at Department of Psychiatry, University of Minnesota (2001-2002), and Division of Endocrinology, Beth Israel Deaconess Medical Center at Harvard Medical School (2002-2005). Then she worked as a Research Assistant Professor at Department of Biology, the Pennsylvania State University. In 2007, she established her lab and worked as a Professor and Principal Investigator in Shanghai Institute of Nutrition and Health, Chinese Academy of Science (CAS). She was also a director of the Key Lab of Nutrition, Metabolism and Food Safety of CAS. In 2022, she joined Fudan University. Dr. Guo has been supported by grants from National Key R&D Program of China, National Science Foundation for Distinguished Young Scholars, the Key Program of National Natural Science Foundation of China (NSFC), and the Major Research Plan of NSFC. Dr. Guo has been awarded State Council Government Special Allowance, Shanghai Leading Talents, Shanghai Excellent Academic Leader, Shanghai Women's Innovation Award, and the title of March 8 Red-banner pacesetter. As a corresponding author, Dr. Guo has published over 40 papers, including in Gastroenterology, Nature Communications, Autophagy and 14 in Diabetes.

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Recently there has been an increase in the global prevalence of metabolic syndrome including obesity, diabetes and fatty liver. Metabolic syndrome also causes a variety of neurologic events such as depression and anxiety. However, the underlying mechanisms remain largely unknown. Maintenance of metabolic homeostasis and the response to nutritional and environmental challenges require the coordination of multiple organs. The central nervous system (CNS) regulates feeding behavior and peripheral organ functions via neuropeptides or neuroendocrine pathways. On the other hand, afferent nerves and secreted proteins transmit metabolic information from peripheral organs to CNS. The disturbance of these processes is an important driving factor for metabolic syndrome and related diseases. Therefore, more research is needed to identify mechanisms underlying the crosstalk between CNS and peripheral organs. Currently, we are trying to use tissue-specific knockout mice and cell line models, combined with various tissue injection of adeno-associated virus strategy to address these issues. These studies will help to understand the molecular mechanisms and pathogenesis of metabolic syndrome and relatedneurological disorders, which will contribute to the discovery of new drug targets for treating these diseases. Specific aims include investigating:

1) the role of CNS in regulating metabolic homeostasis;

2) mechanisms underlying signals from peripheral tissues influencing the CNS;

3) nutrient sensing mechanisms underlying metabolic diseases and neurological disorders.